Taking into account the steps for the folding pathway of α-helical membrane proteins and relating biophysical parameters to each of these steps, we create a score capable of predicting the propensity for membrane localization and call it FP3mem.

By creating a score (FP3mem) encompassing the biophysical parameters involved in the folding of α-helical transmembrane proteins, we provide a scale for measuring the propensity of protein sequences for localization within the plasma membrane. This parameter distinguishes membrane proteins from non-membrane proteins in various datasets, and powerfully competes with other methods. Furthermore, FP3mem quantifies a protein’s propensity for becoming an α-helical transmembrane protein.

 

 

Leave a Reply

You must be logged in to post a comment.

  • Note

    Holly Quran: "... If you are able to penetrate the provinces of heaven and earth, pass through them! but you shall not pass through except with a power!"

  • Search