SEPAS

Knowledge about the structure and stability of PPIs is inevitable to decipher the behavior of protein systems. Prediction of protein complexes’ stability is an interesting topic in the field of structural biology. Now to predict the experimentally measured affinity between […]

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Protein Target Finding

Our observations indicate that the mechanical properties of protein binding sites have a decisive impact on determining the dimer stability…. Imagine that a ligand protein touches the surface of its receptor upon collision to find the right binding site…[full story […]

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PARDIS

… We introduce a new method for predicting dissociation free energy of subunits by analyzing the structural and topological properties of a protein binding patch on a single subunit of the desired protein complex. The method needs the 3D structure […]

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DNA in Porin

… We study the interactions of OmpF with pentameric poly-nucleotides (poly-Ns) in silico. The poly-N molecule is forced to translocate through the lumen of OmpF. Subsequently, the structural and dynamical effects of translocation steps on protein and poly-N molecules are […]

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in-silico Drug Design

…. Two specific endoplasmic reticulum calcium channels, ryanodine receptors (RyRs) and inositol 1,4,5-trisphosphate receptors (IP3Rs) play an important role in Ca2+ regulation. In the present study, we provided a 3D structure of RyR and IP3R by homology modeling, and we […]

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Blog

Knowledge about the structure and stability of PPIs is inevitable to decipher the behavior of protein systems. Prediction of protein complexes’ stability is an interesting topic in the field of structural biology. Now to predict the experimentally measured affinity between […]

Read More

Our observations indicate that the mechanical properties of protein binding sites have a decisive impact on determining the dimer stability…. Imagine that a ligand protein touches the surface of its receptor upon collision to find the right binding site…[full story […]

Read More

… We introduce a new method for predicting dissociation free energy of subunits by analyzing the structural and topological properties of a protein binding patch on a single subunit of the desired protein complex. The method needs the 3D structure […]

Read More

… We study the interactions of OmpF with pentameric poly-nucleotides (poly-Ns) in silico. The poly-N molecule is forced to translocate through the lumen of OmpF. Subsequently, the structural and dynamical effects of translocation steps on protein and poly-N molecules are […]

Read More