Knowledge about the structure and stability of PPIs is inevitable to decipher the behavior of protein systems. Prediction of protein complexes’ stability is an interesting topic in the field of structural biology. Now to predict the experimentally measured affinity between protein monomers in solution we just need the 3D structure of suggested PBP on one subunit of the proposed dimer. […]

Our observations indicate that the mechanical properties of protein binding sites have a decisive impact on determining the dimer stability…. Imagine that a ligand protein touches the surface of its receptor upon collision to find the right binding site…[full story at JBSD]

… We introduce a new method for predicting dissociation free energy of subunits by analyzing the structural and topological properties of a protein binding patch on a single subunit of the desired protein complex. The method needs the 3D structure of just one subunit and the information about the position of the intended binding site on the surface of that […]

… We study the interactions of OmpF with pentameric poly-nucleotides (poly-Ns) in silico. The poly-N molecule is forced to translocate through the lumen of OmpF. Subsequently, the structural and dynamical effects of translocation steps on protein and poly-N molecules are explored in detail…[full story at PCB]

…. Two specific endoplasmic reticulum calcium channels, ryanodine receptors (RyRs) and inositol 1,4,5-trisphosphate receptors (IP3Rs) play an important role in Ca2+ regulation. In the present study, we provided a 3D structure of RyR and IP3R by homology modeling, and we predicted their interactions with a known neuroprotective compound, 3-thiomethyl-5,6-(dimethoxyphenyl)-1,2,4-triazine (TDMT), as well as two inhibitors, dantrolene and 2-aminoethoxydiphenyl borate (2-APB)….